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KMID : 0358419970400040872
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Korean Journal of Obstetrics and Gynecology
1997 Volume.40 No. 4 p.872 ~ p.878
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Clinical Significance of Urinary Epidermal Growth Factor in Gynecologic Tumors
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유근재/Yoo, Keun Jai
이원욱/이성기/김종석/최범채/김수녕/Lee, Won Wook/Lee, Sung Ki/Kim, Jung Seok/Choi, Bum Chae/Kim, Soo Nyung
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Abstract
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Objectives: The purpose of this study was to get the clinical significance of urinary concentration of epidermal growth factor(EGF) of the patients with benign and malignant gynecologic tumors compared to normal control group.
Methods: We studied the urinary EGF levels in 73 patients with gynecologic tumors at Min-Joong General Hospital of KonKuk University. The collected samples were treated by radioimmunoassay technique. Chi-square analysis and Student´s t-test were used. Significance was determined at the level of p<0.05.
Results: In 73 cases, benign gynecologic tumors were 54 cases and gynecologic cancers were 19 cases(cervical cancer 8, ovarian cancer 8, other gynecologic cancer 3). The mean age of the patients with benign gynecologic tumors was 38 years old and 40 years old in gynecologic cancers. The mean urinary EGF levels of the patients with benign gynecologic tumors was 16.4±6.6 nglmg. creatinine, and 16.1±4.7 nglmg. creatinine in gynecologic cancers(15.3±4.3 ng/mg. creatinine in cervical cancer, 16.4±3.7 ng/mg. creatinine in ovarian cancers), 16.7±3.7 ng/mg. creatinine in normal control grop. There was no significant difference in urinary EGF levels between control group and the patients with gynecologic tumors. There was no significant difference in urinary EGF levels between benign gynecologic tumors and gynecologic cancers.
Conclusion: Our data suggest that urinary EGF may not be useful as a marker of gynecologic tumors. growth factor receptor status as predictor of early recu- rrence of and death from breast cancer. Lancet 1987 ; 1398. Tahara
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